Drug design
Drug Design
Drug design, also known as Rational drug design or Molecular design, is the inventive process of finding new medications based on the knowledge of a biological target.
Pronunciation
Drug Design: /drʌɡ dɪˈzaɪn/
Etymology
The term "drug design" is derived from the fields of Pharmacology and Medicinal Chemistry, where scientists aim to design and synthesize new therapeutic agents.
Process
Drug design involves the design of small molecules that are complementary in shape and charge to the biomolecular target to which they interact and therefore will bind to it. This process involves a thorough understanding of the biochemical and physiological aspects of disease processes, as well as the application of computational methods in handling the complex data involved.
Related Terms
- Lead compound: A compound that exhibits pharmacological properties which suggest its therapeutic potential.
- Pharmacophore: An abstract description of molecular features which are necessary for molecular recognition of a ligand by a biological macromolecule.
- Bioisostere: Chemicals or groups with similar steric or electrostatic properties which produce broadly similar biological properties to another chemical compound.
- Quantitative structure-activity relationship (QSAR): A method for predicting the potency of a drug by comparing it to similar compounds with known activities.
See Also
External links
- Medical encyclopedia article on Drug design
- Wikipedia's article - Drug design
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