Dexchlorpheniramine

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Information about Dexchlorpheniramine

Brompheniramine and chlorpheniramine maleate are first generation antihistamines that are widely used to treat symptoms of allergic rhinitis and the common cold.

Liver safety of Dexchlorpheniramine

Clinically apparent liver injury from brompheniramine or chlorpheniramine must be exceeding rare, if it occurs at all.

Mechanism of action of Dexchlorpheniramine

Brompheniramine (brome" fen ir' a meen) and chlorpheniramine (klor" fen ir' a meen) are first generation antihistamines that are used widely in the therapy of the symptoms of sneezing, cough, runny note, watery eyes and itching. They are similar in chemical structure and constitute the alkylamine class of antihistamines. They are probably the most commonly used over-the-counter antihistamines, being present alone or in combination with other agents in more than 1000 products used for the symptoms of the common cold, sinusitis, urticaria and hay fever.

Isomers

Both agents are also available as their dextrorotatory isomers, dexbrompheniramine and dexchlorpheniramine, which have similar profiles of action and side effects.

Isomers: Brompheniramine and Chlorpheniramine

Isomers: Dexbrompheniramine and Dexchlorpheniramine

Brand name for Dexchlorpheniramine

Common brand name preparations include Chlor-Trimeton, Dimetane, Drixoral and Durahist, and most are available without a prescription and in combination with sympathomimetic agents (such as pseudoephedrine or phenylephrine) or analgesics or both.

Dosage and administration for Dexchlorpheniramine

The typical oral dose in adults is 2 to 4 mg three or four times a day.

Side effects of Dexchlorpheniramine

Common side effects include sedation, impairment of motor function, confusion, dizziness, blurred vision, dry mouth and throat, palpitations, tachycardia, abdominal distress, constipation and headache. Antihistamines can worsen urinary retention and glaucoma.

First Generation Antihistamines

Second Generation Antihistamines


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