Deferiprone

From WikiMD

Information about Deferiprone

Deferiprone is an oral iron chelating agent used to treat transfusion related, chronic iron overload. 

Liver safety of Deferiprone

Deferiprone has been linked to a low rate of transient serum aminotransferase elevations during therapy and to rare instances of clinically apparent liver injury.

Mechanism of action of Deferiprone

Deferiprone (de fer’ i prone) is an orally available iron chelating agent that binds iron with a high affinity and zinc and copper to a lesser extent.  In clinical trials in patients with transfusion related iron overload, deferiprone therapy lowered both circulating and tissue (cardiac, liver) iron levels and maintained reduced iron concentrations in patients previously treated long term with subcutaneous infusions of deferoxamine. 

FDA approval information for Deferiprone

Deferiprone was approved for use in Europe in 1994, but was not approved in the United States until 2011.  Current indications are restricted to patients with transfusion related iron overload due to thalassemic syndromes. 

Dosage and administration for Deferiprone

Deferiprone is available in tablets of 500 mg under the brand name Ferriprox.  The recommended dose is 25 to 33 mg/kg three times daily. 

Side effects of Deferiprone

Side effects can include nausea, abdominal pain, arthralgias and neutropenia (6%).  Severe adverse events include agranulocytosis (1% to 2%) and infections.  Weekly monitoring of white blood cell counts is recommended.


Arsenic Chelators

Copper Chelators (for Wilson Disease)

Iron Chelators

Lead Chelators

Mercury Chelators


The article on Deferiprone is a stub. YOU can help Wikimd by expanding it!

Medication resources

Learn more


edit 

About WikiMD

About us: WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Our mission: Provide up to date physician reviewed health, nutrition and wellness information for free in over 100 languages.

Join us: This article is a stub. Help improve Deferiprone or others. Do not trust amateurs with your life! Join us in this effort!. Paid editors welcome.

Pubmed.png Uptodate.png Wikipedia Reddit YouTube videos
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*

Quick links: Medicine Portal | Encyclopedia‏‎‏‎ | Gray's Anatomy‏‎ | Topics‏‎ |‏‎ Diseases‏‎ | Drugs | Wellness | Obesity‏‎ | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="http://www.wikimd.org/wiki/Deferiprone">Deferiprone</a>

  • Individual results may vary for weight loss from our sponsors.