Darier's sign
Darier's Sign
Darier's sign (pronounced: dah-ree-ayz sign) is a clinical dermatological term used to describe a specific skin response in certain mast cell diseases, most notably Mastocytosis and Urticaria Pigmentosa.
Etymology
The term is named after the French dermatologist Ferdinand-Jean Darier, who first described the sign in 1889.
Definition
Darier's sign refers to the appearance of a wheal and flare reaction, which is a red, itchy, and swollen area of skin, when the skin is lightly stroked or rubbed. This reaction is due to the release of histamine and other inflammatory mediators from mast cells in the skin.
Related Terms
- Mastocytosis: A group of disorders characterized by an abnormal accumulation of mast cells in the skin, bone marrow, and internal organs.
- Urticaria Pigmentosa: A form of mastocytosis that affects the skin.
- Histamine: A compound that is released by cells in response to injury and in allergic and inflammatory reactions, causing contraction of smooth muscle and dilation of capillaries.
- Wheal and flare: A common skin reaction to allergens, characterized by a raised, red, itchy patch of skin (wheal) surrounded by an area of redness (flare).
See Also
External links
- Medical encyclopedia article on Darier's sign
- Wikipedia's article - Darier's sign
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