Dactinomycin

From WikiMD

dactinomycin  (DAK-tih-noh-MY-sin) is a drug used to treat Ewing sarcoma, gestational trophoblastic tumor, Wilms tumor, and certain types of testicular cancer. It is also used to treat rhabdomyosarcoma in children. It is being studied in the treatment of other types of cancer. Dactinomycin comes from the bacterium Streptomyces parvulus. It damages the cell’s DNA and may kill cancer cells. It is a type of anticancer antibiotic. Also called actinomycin D and Cosmegen.

Information about Dactinomycin

Dactinomycin is an intravenously administered, antineoplastic antibiotic that is used in the treatment of solid tumors in children and choriocarcinoma in adult women.

Liver safety of Dactinomycin

In high doses, dactinomycin can cause severe liver injury including sinusoidal obstruction syndrome.

Mechanism of action of Dactinomycin

Dactinomycin (dak” tin oh mye’ sin) is one of the actinomycins, anticancer antibiotics that were discovered by Selman Waksman and colleagues in the 1940s using fermentation exacts from bacteria (Streptomyces). The actinomycins are chromopeptides which bind to double-helical DNA and interrupt RNA transcription, causing cell arrest and inhibition of cell division. Actinomycin D, later named dactinomycin, was isolated from Streptococcus parvullus and was identified as a promising antineoplastic agent. Subsequently, dactinomycin was shown to have antitumor effect against a broad array of solid tumors.

FDA approval information for Dactinomycin

Dactinomycin was formally approved for use in the United States in 1964 and continues to be a valuable agent in the therapy of solid tumors of childhood (Wilms tumor, rhabdomyosarcoma) and in choriocarcinoma in adult women. Dactinomycin is available as a solution or lyophilized powder for injection in vials of varying concentrations under the commercial name Cosmegen and must be given by the intravenous route, avoiding tissue extravasation.

Dosage and administration for Dactinomycin

The dose is based upon indication and body weight; a typical regimen is 10 to 15 mcg/kg daily for 5 days, with repeat courses every 2 to 4 weeks based upon tolerance and antitumor effects. Dactinomycin can also be given as a component of regional perfusion regimens for solid malignancies.

Side effects of Dactinomycin

side effects of dactinomycin include bone marrow suppression, anorexia, nausea, diarrhea, glossitis, proctitis, oral ulcers, alopecia, erythema and skin rash.


The article on Dactinomycin is a stub. YOU can help Wikimd by expanding it!

Medication resources

Learn more


edit 

About WikiMD

About us: WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Our mission: Provide up to date physician reviewed health, nutrition and wellness information for free in over 100 languages.

Join us: This article is a stub. Help improve Dactinomycin or others. Do not trust amateurs with your life! Join us in this effort!. Paid editors welcome.

Pubmed.png Uptodate.png Wikipedia Reddit YouTube videos
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*

Quick links: Medicine Portal | Encyclopedia‏‎‏‎ | Gray's Anatomy‏‎ | Topics‏‎ |‏‎ Diseases‏‎ | Drugs | Wellness | Obesity‏‎ | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="http://www.wikimd.org/wiki/Dactinomycin">Dactinomycin</a>

  • Individual results may vary for weight loss from our sponsors.