DNA laddering
DNA Laddering
DNA laddering is a distinctive pattern of DNA fragmentation that occurs during apoptosis. It is the result of the activation of cellular endonucleases which cleave the DNA into fragments that are multiples of 180-200 base pairs.
Pronunciation
- DNA: /diː.eɪ.en.eɪ/
- Laddering: /ˈlædərɪŋ/
Etymology
The term "DNA laddering" is derived from the appearance of these fragments on an agarose gel, which resembles a ladder. The term "DNA" is an acronym for deoxyribonucleic acid, the molecule that carries genetic instructions in all living organisms and many viruses.
Related Terms
- Apoptosis: A form of programmed cell death that occurs in multicellular organisms.
- Endonuclease: An enzyme that cleaves the phosphodiester bond within a polynucleotide chain.
- Agarose gel electrophoresis: A method used in biochemistry and molecular biology to separate DNA, RNA, or protein molecules by size.
- DNA fragmentation: The separation or breaking up of DNA strands into smaller fragments.
See Also
- Caspase: A family of protease enzymes playing essential roles in programmed cell death.
- Nuclease: An enzyme capable of cleaving the phosphodiester bonds between the nucleotide subunits of nucleic acids.
References
External links
- Medical encyclopedia article on DNA laddering
- Wikipedia's article - DNA laddering
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski