Crossover
Crossover (Medicine)
Crossover (pronounced: /ˈkrɒsˌoʊvər/) is a term used in various fields of medicine, with different meanings depending on the context.
Etymology
The term "crossover" originates from the English words "cross" and "over", indicating a transition or change from one state or condition to another.
Definitions
In Genetics, a crossover refers to the exchange of genetic material between two homologous chromosomes during meiosis, resulting in new combinations of genes in the offspring. This process is also known as genetic recombination.
In Clinical Trials, a crossover study is a type of longitudinal study in which subjects receive a sequence of different treatments or exposures over time. This design is often used in pharmaceutical trials to compare the effectiveness of different drugs or treatments.
In Physiology, the crossover concept is used in the context of the Crossover Point Theory, which describes the shift from aerobic to anaerobic metabolism during incremental exercise.
Related Terms
- Homologous Chromosomes: A pair of chromosomes containing the same linear gene sequences, each derived from one parent.
- Meiosis: A type of cell division that results in four daughter cells each with half the number of chromosomes of the parent cell.
- Genetic Recombination: The production of offspring with combinations of traits that differ from those found in either parent.
- Clinical Trial: Research studies performed in people that are aimed at evaluating a medical, surgical, or behavioral intervention.
- Crossover Point Theory: A theory that describes the shift from aerobic to anaerobic metabolism during incremental exercise.
External links
- Medical encyclopedia article on Crossover
- Wikipedia's article - Crossover
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