Doctor in scrubs


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
28,899 pages, 4,107,258 edits & 35,688,120 views.

Free unbiased diet, health and wellness info!

Crizotinib

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Information about Crizotinib

Crizotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of selected cases of advanced non-small cell lung cancer. 

Crizotinib
Crizotinib

Liver safety of Crizotinib

Crizotinib is associated with transient elevations in serum aminotransferase levels during treatment and rare instances of clinically apparent acute liver injury that can be severe and even fatal. 

Mechanism of action of Crizotinib

Crizotinib (kriz oh’ ti nib) is an orally available, small molecule inhibitor of the tyrosine kinase receptor of mutated anaplastic lymphoma kinase (ALK), which is the result of a chromosomal translocation found in about 5% of lung cancers.  Patients with non-small cell lung cancer with the ALK mutation often respond to crizotinib therapy with shrinkage of the tumor and apparent improvement in survival. 

FDA approval information for Crizotinib

Crizotinib received accelerated approval for use in the United States in 2011 for the treatment of advanced non-small cell lung cancer with the ALK translocation (a test for this genetic rearrangement was also approved). 

Dosage and administration for Crizotinib

Crizotinib is available in capsules of 200 and 250 mg under the brand name Xalkori.  The recommended dose is 250 mg by mouth twice daily, with dose modification based upon tolerance. 

Side effects of Crizotinib

Side effects are common and include diarrhea, nausea, vomiting, anorexia, fatigue, constipation, visual disturbances and edema.  Uncommon, but potentially serious side effects include interstitial lung disease, QTc interval prolongation and bradycardia. 

Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ

 

Cost and Coupons - Crizotinib

Reviews for Crizotinib

Learn more about Crizotinib

Latest research (Pubmed)

PubMed
Wikipedia

External links


edit 

WikiMD needs you!

This WikiMD article Crizotinib is a stub.
If you are a healthcare professional familiar with the topic Crizotinib, or
A subject matter expert or authority on Crizotinib, you can help us.
About | Mission | Paid editors welcome!

Crizotinib is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever!
Medicine: Health - Encyclopedia‏‎‏‎ - Topics‏‎ -‏‎ Diseases‏‎ - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity‏‎ - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP*
Special: W8MD's tele-weight loss consultations only $99.99. Call 718-946-5500. Limited acceptance.