Cortisone acetate

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Cortisone Acetate

Cortisone acetate (/kɔːrˈtɪsoʊn ˈæsɪteɪt/) is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is a derivative of cortisone, which is converted into hydrocortisone, or cortisol, in the body. Cortisone acetate is used to treat a variety of medical conditions that cause inflammation.

Etymology

The term "cortisone" is derived from the Latin cortex, meaning "bark", as the hormone was first isolated from the adrenal cortex of the adrenal gland. The "acetate" suffix indicates that the cortisone has been chemically combined with acetic acid to form a more stable compound.

Medical Uses

Cortisone acetate is used to treat a variety of conditions that involve inflammation. These include rheumatoid arthritis, lupus, asthma, allergies, and certain skin conditions. It is also used to treat conditions related to a deficiency of the adrenal cortex hormones such as Addison's disease.

Pharmacology

Cortisone acetate is a prodrug of cortisol. It is metabolized in the liver by the enzyme esterase to its active form, cortisol. Cortisol has potent anti-inflammatory and immunosuppressive properties.

Side Effects

Like all corticosteroids, cortisone acetate can cause a range of side effects. These can include weight gain, mood changes, osteoporosis, and increased susceptibility to infections. Long-term use can lead to Cushing's syndrome, a condition characterized by a round face, upper body obesity, skin thinning, and bone loss.

See Also

External links

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