Cloprostenol

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Cloprostenol (pronounced klo-pros-ten-ol) is a synthetic prostaglandin analogue that is primarily used in veterinary medicine. It is a potent luteolytic agent, used to manipulate the estrous cycle of livestock by inducing luteolysis, the regression of the corpus luteum.

Etymology

The term "Cloprostenol" is derived from the chemical structure of the compound. The prefix "Clo-" refers to chlorine, a component of the compound, while "prostenol" is a common suffix for prostaglandin analogues.

Pharmacology

Cloprostenol functions by binding to prostaglandin F2alpha (PGF2α) receptors, which are found in high concentrations in the corpus luteum. This binding triggers a cascade of events that ultimately leads to luteolysis. The regression of the corpus luteum results in a rapid drop in progesterone levels, which can trigger estrus and/or parturition in livestock.

Usage

In veterinary medicine, cloprostenol is used to control the timing of estrus and parturition in livestock, particularly in swine and cattle. It is also used to treat certain reproductive disorders, such as pyometra and chronic endometritis.

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