Citrin
Citrin
Citrin (pronounced /ˈsɪtrɪn/) is a protein that in humans is encoded by the SLC25A13 gene. It plays a crucial role in the urea cycle and the malate-aspartate shuttle.
Etymology
The term "citrin" comes from the Latin word citrus, referring to the citrus fruit, which is rich in citric acid. The name was given due to the protein's role in the citric acid cycle, also known as the Krebs cycle or the tricarboxylic acid cycle.
Function
Citrin is a mitochondrial carrier protein that transports glutamate, aspartate, and other metabolites across the mitochondrial membrane. It is essential for the process of gluconeogenesis, the synthesis of glucose from non-carbohydrate sources, and the maintenance of blood glucose levels.
Related Terms
- Citrin deficiency: A condition caused by mutations in the SLC25A13 gene, leading to a deficiency of the citrin protein. It can result in a variety of symptoms, including failure to thrive, growth retardation, and liver disease.
- Citrullinemia: A disorder that leads to an accumulation of citrulline, an amino acid, in the blood. Citrin plays a role in the urea cycle, which is disrupted in citrullinemia.
- Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD): A condition that affects the liver during infancy, caused by a deficiency of the citrin protein.
See Also
External links
- Medical encyclopedia article on Citrin
- Wikipedia's article - Citrin
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