Ciglitazone
Ciglitazone
Ciglitazone (pronounced as sig-li-ta-zone) is a thiazolidinedione derived oral hypoglycemic agent used in the treatment of diabetes mellitus type 2. It is a member of the glitazone class of drugs, which function by activating peroxisome proliferator-activated receptor gamma (PPARγ), a type of nuclear regulatory protein involved in transcription of genes regulating glucose and fat metabolism.
Etymology
The term 'Ciglitazone' is derived from the class of drugs it belongs to, 'glitazone', with the prefix 'Cig' being an arbitrary designation. The 'glitazone' part of the name is a common suffix for drugs in the thiazolidinedione class.
Pharmacology
Ciglitazone, like other glitazones, works by binding to PPARγ receptors in fat cells and making the cells more responsive to insulin. This results in decreased insulin resistance, which can help control blood glucose levels in patients with type 2 diabetes.
Related Terms
- Thiazolidinedione: A class of drugs that includes ciglitazone. They are used to treat diabetes by decreasing insulin resistance.
- Glitazone: A subclass of thiazolidinediones, which includes drugs like ciglitazone, pioglitazone, and rosiglitazone.
- Peroxisome proliferator-activated receptor gamma (PPARγ): A type of nuclear regulatory protein that is activated by glitazones like ciglitazone.
- Insulin resistance: A condition in which cells in the body become resistant to the effects of insulin, leading to higher blood sugar levels. It is a common characteristic of type 2 diabetes.
See Also
External links
- Medical encyclopedia article on Ciglitazone
- Wikipedia's article - Ciglitazone
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