Chronic granulomatous disease
Chronic Granulomatous Disease
Chronic granulomatous disease (CGD; /ˈkrɒnɪk ˌɡrænjʊˈloʊmətəs dɪˈziːz/), is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming granulomas, a type of inflammation that walls off infections. The name comes from the Greek words "chronos" (meaning "time") and "granuloma" (meaning "small grain"), referring to the long-term, grain-like nodules that form in this condition.
Causes
CGD is caused by a defect in the NADPH oxidase complex, which reduces the ability of neutrophils and macrophages to kill certain types of bacteria and fungi. This defect is inherited in an X-linked recessive or autosomal recessive manner.
Symptoms
Symptoms of CGD can vary greatly, but often include recurrent bacterial infections and fungal infections, granuloma formation, and inflammation in various parts of the body.
Diagnosis
Diagnosis of CGD is typically made through a series of tests, including a blood test to measure the function of the neutrophils, and genetic testing to identify the specific mutation causing the disease.
Treatment
Treatment for CGD typically involves managing infections with antibiotics and antifungal medication, and in severe cases, a bone marrow transplant may be considered.
Prognosis
With early diagnosis and appropriate treatment, many people with CGD can lead relatively normal lives. However, the disease can be life-threatening if not properly managed.
See Also
External links
- Medical encyclopedia article on Chronic granulomatous disease
- Wikipedia's article - Chronic granulomatous disease
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski