Central chromatolysis
Central chromatolysis (pronounced: cen-tral kro-ma-to-ly-sis) is a pathological condition observed in the cell body of a neuron, characterized by the dispersion of Nissl bodies from the center to the periphery. It is often a response to axonal injury.
Etymology
The term "central chromatolysis" is derived from three Greek words: "kentron" meaning center, "chroma" meaning color, and "lysis" meaning loosening.
Definition
Central chromatolysis is a cellular change observed in neurons when they are subjected to stress or injury. This process is characterized by the dispersion or dissolution of Nissl bodies, which are large granular bodies found in neurons. These bodies are made up of rough endoplasmic reticulum and free ribosomes, and are responsible for protein synthesis in the neuron. In central chromatolysis, these Nissl bodies move from the center of the neuron to the periphery, leaving the center of the neuron clear.
Causes
Central chromatolysis is often a response to axonal injury. It can also occur due to other forms of stress or damage to the neuron, such as ischemia, hypoxia, or exposure to toxins.
Related Terms
- Neuron: The basic working unit of the brain, a specialized cell designed to transmit information to other nerve cells, muscle, or gland cells.
- Nissl bodies: Large granular bodies found in neurons, made up of rough endoplasmic reticulum and free ribosomes, responsible for protein synthesis.
- Axon: A long, slender projection of a nerve cell, or neuron, that conducts electrical impulses away from the neuron's cell body.
- Ischemia: A condition in which there is insufficient blood flow to the brain to meet metabolic demand.
- Hypoxia: A condition in which there is not enough oxygen available to the brain to meet metabolic demand.
External links
- Medical encyclopedia article on Central chromatolysis
- Wikipedia's article - Central chromatolysis
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski