Cefiderocol
Cefiderocol
Cefiderocol (pronounced as sef-uh-DARE-oh-kol) is an antibiotic medication used to treat bacterial infections. It is particularly effective against Gram-negative bacteria due to its unique mechanism of action.
Etymology
The name "Cefiderocol" is derived from the class of antibiotics it belongs to, known as Cephalosporins, and its unique iron-chelating property. The suffix "-col" is a reference to its ability to bind to iron, which is represented by the symbol "Fe" in the periodic table.
Mechanism of Action
Cefiderocol works by binding to the Penicillin-Binding Proteins (PBPs) present in the bacterial cell wall, inhibiting the synthesis of the bacterial cell wall and leading to cell death. Additionally, it uses a unique iron transport mechanism to penetrate the outer membrane of Gram-negative bacteria, enhancing its effectiveness against these types of bacteria.
Related Terms
Usage
Cefiderocol is used to treat a variety of bacterial infections, particularly those caused by Gram-negative bacteria. It is often used when other antibiotics are ineffective due to bacterial resistance.
Side Effects
Common side effects of Cefiderocol include diarrhea, nausea, and changes in liver function tests. More serious side effects may include allergic reactions, Clostridium difficile-associated diarrhea, and alterations in blood clotting.
Precautions
Before using Cefiderocol, patients should inform their healthcare provider about any allergies, medical conditions, or other medications they are taking. It is also important to monitor for signs of an allergic reaction while taking this medication.
External links
- Medical encyclopedia article on Cefiderocol
- Wikipedia's article - Cefiderocol
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