Captopril suppression test

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Captopril Suppression Test

The Captopril Suppression Test (pronounced: cap-toe-pril suh-preh-shun test) is a diagnostic procedure used primarily in the field of Endocrinology to evaluate for Primary Aldosteronism, a condition characterized by excessive secretion of the hormone aldosterone from the adrenal glands.

Etymology

The term "Captopril" is derived from the chemical name (2S)-1-[(2S)-2-Methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid. It is a type of ACE inhibitor used in the test. "Suppression" refers to the intended effect of the medication on aldosterone production.

Procedure

The Captopril Suppression Test involves the oral administration of Captopril, an ACE inhibitor, and subsequent measurement of blood pressure and blood levels of aldosterone and renin. An abnormal response to the test (i.e., lack of expected suppression of aldosterone) suggests the presence of Primary Aldosteronism.

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