Capreomycin
Capreomycin
Capreomycin (pronounced as kapreeohmyesin) is a cyclic peptide antibiotic derived from the bacterium Streptomyces capreolus. It is primarily used in the treatment of tuberculosis.
Etymology
The term "Capreomycin" is derived from the bacterium Streptomyces capreolus from which it is isolated. The suffix "-mycin" is commonly used in the nomenclature of antibiotics, indicating its microbial origin.
Usage
Capreomycin is used in combination with other antitubercular drugs to treat multi-drug resistant tuberculosis (MDR-TB). It is not used as a first-line treatment, but is reserved for cases where other treatments have failed or cannot be used.
Mechanism of Action
Capreomycin works by inhibiting protein synthesis in bacteria. It binds to the 70S ribosomal subunit, interfering with the translocation process. This prevents the bacteria from producing essential proteins, thereby inhibiting their growth and reproduction.
Side Effects
Common side effects of Capreomycin include kidney damage, hearing loss, and electrolyte imbalance. It may also cause allergic reactions in some individuals.
Related Terms
- Antibiotic
- Tuberculosis
- Antitubercular drugs
- Multi-drug resistant tuberculosis (MDR-TB)
- 70S ribosomal subunit
- Protein synthesis
External links
- Medical encyclopedia article on Capreomycin
- Wikipedia's article - Capreomycin
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