Clostridioides difficile

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Clostridioides difficile (klos-TRID-e-oy-dees dif-uh-SEEL) is a bacterium that causes inflammation of the colon, known as colitis.

Pronunciation

The term is pronounced as klos-TRID-e-oy-dees dif-uh-SEEL.

Etymology

The name Clostridioides difficile is derived from the Greek word "kloster" meaning spindle, and the Latin word "difficile" meaning difficult. This refers to the bacterium's spindle-like shape and its resistance to treatment.

Description

Clostridioides difficile is a Gram-positive, spore-forming, obligate anaerobic, toxin-producing bacterium. It is a major cause of antibiotic-associated diarrhoea and can lead to pseudomembranous colitis, a severe infection of the colon, often resulting from eradication of the normal gut flora by antibiotics.

Symptoms

Symptoms of Clostridioides difficile infection include watery diarrhea, fever, loss of appetite, nausea, and abdominal pain.

Treatment

Treatment for Clostridioides difficile infection typically involves stopping the use of the antibiotic that triggered the infection, and starting a course of antibiotics that can kill the Clostridioides difficile bacteria. In severe cases, surgery may be required to remove the diseased portion of the colon.

Prevention

Prevention of Clostridioides difficile infection involves proper hand hygiene, careful use of antibiotics, and thorough cleaning of surfaces in healthcare settings.

Related Terms

External links

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