CD40

CD40

CD40 (pronounced: C-D-Forty) is a Costimulatory molecule that is expressed on Antigen presenting cells (APCs) and is required for their activation. The binding of CD40 with its ligand, CD40L, is important in the process of Immune response.

Etymology

The term "CD40" is derived from the term "Cluster of Differentiation 40". The Cluster of Differentiation is a protocol used for the identification and investigation of cell surface molecules present on Leukocytes.

Function

CD40 is a Receptor that is primarily present on the surface of B cells. It plays a crucial role in B cell activation and differentiation. The interaction between CD40 and its ligand, CD40L, is necessary for the production of Antibodies and the development of Memory B cells and Germinal centers in the Lymph nodes.

Related Terms

• CD40L: The ligand for CD40, expressed on the surface of T cells.
• B cells: A type of white blood cell that produces antibodies.
• T cells: A type of white blood cell that plays a central role in cell-mediated immunity.
• Antigen presenting cells: Cells that display antigens complexed with major histocompatibility complexes on their surfaces.
• Immune response: The reaction of the cells and fluids of the body to the presence of a substance which is not recognized as a constituent of the body itself.

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