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Bisacodyl
Information about Bisacodyl
Bisacodyl is commonly used, over-the-counter laxative used to treat constipation or bowel irregularity.
Liver safety of Bisacodyl
Bisacodyl has not been associated with serum enzyme elevations during therapy or with clinically apparent liver injury with jaundice.
Mechanism of action of Bisacodyl
Bisacodyl (bis ak’ oh dil) is a mild laxative that is available over-the-counter and is commonly used to treat mild constipation and bowel irregularity. Bisacodyl is believed to act by direct stimulation of intestinal peristalsis. Bisacodyl is a diphenylmethane derivative and is structurally similar to phenolphthalein. It is administered in an enteric coated form and is minimally absorbed, acting locally on the large intestine.
FDA approval information for Bisacodyl
Bisacodyl has been in general use since the 1950s and is available in multiple forms including tablets of 5 mg, suppositories of 10 mg and as a liquid solution for oral use generically and under multiple trade names such as Dulcolax, Fleet’s enema, Correctal and Carter’s Little Pills.
Clinical use of Bisacodyl
Bisacodyl is often used for bowel cleansing before operations or colonoscopy.
Side effects of Bisacodyl
Common side effects include abdominal pain, bloating and diarrhea.
Antidiarrheal agents
Antidiarrheal agents include bulk forming agents, hydroscopic agents, bile acid resins, bismuth, inhibitors of intestinal motility, non-absorbed antibiotics and hormones. Bulk forming agents include methylcellulose; hydroscopic agents include pectin and kaolin; bile acid resins are cholestyramine, colestipol and colesevalam; inhibitors of intestinal motility include opioids such as diphenoxylate and loperamide. Antibiotics include rifamycin and rifaximin which are non-absorbed and are used for travelers' diarrhea. Hormones with antidiarrheal activity include octretide and somatostatin. Most antidiarrheal agents are active locally in the small intestine and colon and are largely not absorbed. Some, however, have been implicated in rare causes of liver injury (senna, cascara, cholestyramine). Telotristat is a relatively new agent that inhibits the synthesis of serotonin and is used specifically for the diarrhea of carcinoid syndrome.
- Cholestyramine
- Colesevelam
- Colestipol
- Crofelemer
- Difenoxin
- Diphenoxylate
- Kaolin
- Loperamide
- Methylcellulose
- Octreotide
- Pectin
- Rifamycin
- Rifaximin
- Somatostatin
- Telotristat
Antiemetics are a diverse group of medications that act at different points in the pathways that regulate nausea and vomiting. These include antihistamines, anticholinergic agents, phenothiazines, serotonin type 3 receptor blockers, centrally acting benzamides, cannabinoid receptor agonists, substance P antagonists and miscellaneous.
Anticholinergic Agents
Antihistamines
Cannabinoid Receptor Agonists
- Dronabinol, Nabilone, Tetrahydrocannabinol
- Phenothiazines [See Antipsychotic Agents]
- Chlorpromazine, Prochlorperazine
Serotonin 5-HT3 Receptor Antagonists
Substance P/Neurokinin 1 Receptor Antagonists
Miscellaneous
Acid peptic disease/antiulcer agents that include antacids, the histamine type 2 receptor blockers (H2 blockers), and the proton pump inhibitors (PPIs). These agents are some of the most commonly taken medications and are very well tolerated, most being available both by prescription and over-the-counter. While many of these drugs are approved for use in duodenal and gastric ulcer disease, their major use is for acid reflux and indigestion.
Histamine H2 Receptor Antagonists (H2 Blockers) Cimetidine, Famotidine, Nizatidine, Ranitidine
Cathartics, laxatives or agents for constipation include bulk forming agents, osmotic agents, stool wetting agents, nonspecific stimulants, prokinetic agents and agents that increase fluid secretion. Many of these therapies are not systemically absorbed and none are considered particularly hepatotoxic. Naldemedine and naloxegol are opioid antagonists and are used to treat the constipation associated with opioid use.
- Bisacodyl
- Cascara Sagrada
- Castor Oil
- Docusate
- Fiber, Bran
- Lactulose
- Magnesium Sulfate
- Methylcellulose
- Naldemedine (Opioid Antagonist)
- Naloxegol (Opioid Antagonist)
- Plecanatide (for Chronic Idiopathic Constipation)
- Prucalopride (for Chronic Idiopathic Constipation)
- Senna
Inflammatory bowel disease encompasses several disorders, most commonly ulcerative colitis and Crohn colitis. Agents can be classified as 5-aminosalicyclic acid (5-ASA) based agents, immunosuppressive drugs, antitumor necrosis factor agents, corticosteroids, antibiotics and miscellaneous.
5-Aminosalicyclic Acid (5-ASA) Derivatives
Immunosuppressive Agents
Tumor Necrosis Factor Antagonists
Miscellaneous
Irritable Bowel Syndrome Agents Antimuscarinics/Antispasmodics [See Anticholinergic agents
Prokinetic Agents - See Serotonin 5-ht4 receptor agonists Alosetron, Cisapride, Domperidone, Linaclotide, Lubiprostone, Metoclopramide, Plecanatide, Prucalopride, Tegaserod
Other
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Reviews for Bisacodyl
Learn more about Bisacodyl
- Dailymed label info
- Scientific articles
- Drug portal Bisacodyl
- toxicity info on Bisacodyl
- FDA Bisacodyl
Latest research - Bisacodyl
External links
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