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Bicalutamide

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bicalutamide

(BY-kuh-LOO-tuh-mide)

A drug used with another drug to treat prostate cancer that has spread to other parts of the body. Bicalutamide binds to proteins called androgen receptors, which are found in some prostate cancer cells. These proteins bind to androgens (male hormones)

And may cause cancer cells to grow. Bicalutamide blocks these proteins and may keep cancer cells from growing. It is a type of antiandrogen. Also called Casodex.

Information about Bicalutamide

Bicalutamide is a nonsteroidal antiandrogen similar in structure to flutamide that is used widely in the therapy of prostate cancer.

Liver safety of Bicalutamide

IT has been linked to rare instances of liver injury

Mechanism of action of Bicalutamide

Bicalutamide (bye" ka loo' ta mide) is an orally available nonsteroidal antiandrogen that is similar in structure to flutamide and nilutamide.  Bicalutamide acts by binding to intracellular androgen receptors and competitively inhibiting the action of endogenous androgens on sensitive tissue, including testes, prostate, breast, skin and hypothalamus. 

{fda}} Bicalutamide was approved for use in the United States in 1995.  Current indications are for the therapy of prostate cancer in combination with luteinizing hormone releasing hormone (LHRH) analogs such as leuprolide or goserelin. 

Dosage and administration for Bicalutamide

Bicalutamide is available in tablets of 50 mg generically and under the trade name of Casodex.  The recommended dose is 50 mg once daily.  

Side effects of Bicalutamide

Common side effects of bicalutamide include fatigue, drowsiness, anxiety, gynecomastia and loss of libido

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