Bertilimumab
Bertilimumab
Bertilimumab (pronunciation: ber-til-li-moo-mab) is a human monoclonal antibody designed for the treatment of various inflammatory and autoimmune diseases. It is developed by the biopharmaceutical company Immune Pharmaceuticals.
Etymology
The name "Bertilimumab" follows the World Health Organization's guidelines for the International Nonproprietary Names (INN) of monoclonal antibodies. The suffix "-mab" indicates it is a monoclonal antibody, while the infix "-limu-" suggests it targets the immune system.
Mechanism of Action
Bertilimumab targets and binds to the human eotaxin-1, a potent chemoattractant for eosinophils, a type of white blood cell that plays a key role in the inflammatory response in many diseases. By binding to eotaxin-1, Bertilimumab inhibits the recruitment of eosinophils, thereby reducing inflammation.
Clinical Trials and Uses
Bertilimumab has been investigated in clinical trials for the treatment of Bullous Pemphigoid, Ulcerative Colitis, and Crohn's Disease. It is also being studied for potential use in treating other inflammatory and autoimmune diseases.
Related Terms
- Monoclonal Antibody: A type of protein made in the lab that can bind to substances in the body, including cancer cells.
- Eotaxin-1: A protein that in humans is encoded by the CCL11 gene. It is a potent chemoattractant for eosinophils.
- Eosinophils: A type of disease-fighting white blood cell. This condition may indicate a parasitic infection, an allergic reaction or cancer.
- Inflammation: A process by which the body's white blood cells and substances they produce protect us from infection with foreign organisms, such as bacteria and viruses.
External links
- Medical encyclopedia article on Bertilimumab
- Wikipedia's article - Bertilimumab
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