Information about Benazepril
Benazepril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the therapy of hypertension.
Liver safety of Benazepril
Benazepril is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.
Mechanism of action of Benazepril
Benazepril (ben az' e pril) is an ACE inhibitor which is widely used in the therapy of hypertension. Like other ACE inhibitors, benazepril inhibits the conversion of angiotensin I, a relatively inactive molecule, to angiotensin II which is the major mediator of vasoconstriction and volume expansion induced by the renin-angiotensin system. Other host enzymes besides that which converts angiotensin I to II may be inhibited as well, which may account for some of the side effects of the ACE inhibitors.
FDA approval information for Benazepril
Benazepril was approved for use in the United States in 1991 and current indications are for therapy of hypertension, either alone or in combination with other agents.
Dosage and administration for Benazepril
Benazepril is available in 5, 10, 20 and 40 mg tablets in generic forms and under the trade name Lotensin. The typical dose in adults is 10 mg once daily initially, with gradual adjustment based upon blood pressure response and tolerance. The maximum daily dose is 40 mg in one or two divided doses administered long term. Benazepril is also available in fixed combinations with hydrochlorothiazide (Lotensin HCT and others) and with amlodipine (Lotrel and others).
Side effects of Benazepril
Common side effects include dizziness, fatigue, headache, cough, gastrointestinal upset and skin rash.
Common ACE inhibitors include the following: