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Basiliximab

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Information about Basiliximab

Basiliximab is a chimeric mouse-human monoclonal antibody to CD25, the alpha subunit of the IL-2 receptor, which is found on the surface of T cells. Basiliximab has potent immunosuppressive activity and is used for prevention of organ transplant rejection. Basiliximab has not been linked to serum enzyme elevations during therapy or implicated in cases of clinically apparent liver injury.

Mechanism of action of Basiliximab

Basiliximab (ba” si lix’ i mab) is a recombinant humanized monoclonal IgG1 kappa antibody to the alpha subunit of the IL2 receptor (CD25). The IL2 receptor is found on T cells and its engagement results in activation of T cells and generation of pro-inflammatory cytokines. Inhibition of the receptor with antibody results in prevention of activation and proliferation of T cells and inhibition of T cell responses. Basiliximab has been shown to decrease the rate of acute cellular rejection after solid organ transplantation and to improve long term graft and patient survival.

FDA approval information for Basiliximab

Basiliximab was approved for use in the United States in 1998 for renal transplantation and continues to be used, typically in induction regimens starting at the time of or shortly before transplantation. It is also used off-label for liver, heart and lung transplantation.

Dosage and administration for Basiliximab

Basiliximab has been under evaluation in several autoimmune diseases. Basiliximab is available in powder form in single dose vials of 10 and 20 mg under the brand name Simulect. The recommended regimen of basiliximab is two doses of 20 mg each, each dose given intravenously, the first 2 hours before and the second 4 days after transplantation. The dose in children is 10 mg in the same schedule. Basiliximab should be prescribed only by physicians with experience in immunosuppressive therapy and management of organ transplant patients.

Side effects of Basiliximab

Common side effects include infusion reactions, chills, fever, skin rash, fatigue, diarrhea, nausea, headache, anorexia, leukopenia and infections. Rare, but potentially severe side effects include acute hypersensitivity reactions, anaphylaxis, capillary leak syndrome, cytokine release syndrome and progressive multifocal leukoencephalopathy.

The following drugs used to prevent transplant rejection.

Immunosuppressants

Monoclonal Antibodies

Antithymocyte Globulin

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