Basigin
Basigin
Basigin (pronounced ba-si-gin), also known as CD147 or EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), is a protein that in humans is encoded by the BSG gene.
Pronunciation
- IPA: /bəˈsɪdʒɪn/
Etymology
The term "Basigin" is derived from the Latin word "basis", meaning "base" or "foundation", and the English suffix "-gin", which is derived from the word "origin". This is in reference to the protein's fundamental role in various biological processes.
Function
Basigin is a member of the immunoglobulin superfamily with a wide variety of functions. It plays a crucial role in the development and function of many organs and tissues, including the eye, brain, and heart. It is also involved in the immune response, tumor progression, and inflammation.
Related Terms
- Immunoglobulin superfamily: A large group of proteins involved in the immune response.
- Extracellular Matrix: A three-dimensional network of extracellular macromolecules, such as collagen and glycoproteins, that provide structural and biochemical support to surrounding cells.
- Metalloproteinase: Enzymes that require a metal ion, like zinc or calcium, for their activity. They are involved in many processes, such as cell growth and differentiation, cell migration, angiogenesis, tissue repair, and others.
- Tumor progression: The process by which a tumor grows and spreads.
- Inflammation: A protective response involving immune cells, blood vessels, and molecular mediators to remove harmful stimuli, including damaged cells, irritants, or pathogens.
External links
- Medical encyclopedia article on Basigin
- Wikipedia's article - Basigin
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