Azole
Azole
Azole (/ˈæzoʊl/) is a class of compounds that contain a five-membered heterocyclic ring. The term "azole" is derived from the names of two of the three types of nitrogen heterocycles, azines and diazoles.
Azoles are a group of five-membered heterocyclic compounds containing nitrogen atom(s) and at least one other non-carbon atom (nitrogen, sulfur, or oxygen) as part of the ring. Their names are derived from the Hantzsch–Widman nomenclature. The parent compounds are aromatic and have two double bonds; there are successively fewer double bonds as the non-carbon atoms are reduced in number.
Types of Azoles
Azoles are categorized into two types: Imidazoles and Triazoles. Imidazoles have two nitrogen atoms in the five-member ring, whereas triazoles have three nitrogen atoms.
Imidazoles
Imidazole is an organic compound with the formula C3N2H4. It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. In chemistry, it is an aromatic heterocycle, classified as a diazole, and has non-adjacent nitrogen atoms.
Triazoles
Triazole refers to either one of a pair of isomeric chemical compounds with molecular formula C2H3N3, having a five-membered ring of two carbon atoms and three nitrogen atoms.
Medical Uses
Azoles are widely used in medicine as antifungal agents. They inhibit the synthesis of ergosterol, a critical component of fungal cell membranes. Examples of medical azoles include Clotrimazole, Miconazole, and Fluconazole.
Clotrimazole
Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections such as vaginal yeast infections, oral thrush, and ringworm. It is also used to treat athlete's foot and jock itch.
Miconazole
Miconazole is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections of the skin or vagina.
Fluconazole
Fluconazole is a medication used to treat fungal infections like thrush in the mouth and throat and yeast infections in women.
See Also
External links
- Medical encyclopedia article on Azole
- Wikipedia's article - Azole
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