Azathioprine

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Azathioprine

Azathioprine (pronounced: /ˌæzəˈθaɪəpriːn/) is a medication used primarily in the treatment of certain autoimmune diseases. It is a prodrug, converted in the body to the active metabolite 6-mercaptopurine.

Etymology

The term "Azathioprine" is derived from the prefix "aza-" which indicates the presence of nitrogen, and "thiopurine", which refers to its classification as a purine analogue.

Usage

Azathioprine is used to prevent the body's immune system from fighting transplanted organs such as the heart, liver, and kidney. This helps prevent the body from rejecting the transplanted organ. It is also used to treat rheumatoid arthritis, a condition where the body's immune system attacks the joints causing pain, swelling, and loss of function.

Side Effects

Common side effects of Azathioprine include nausea, vomiting, and diarrhea. Serious side effects may include bone marrow suppression, liver disease, and an increased risk of lymphoma.

Related Terms

  • Immunosuppressive drug: A type of drug that lowers the body's normal immune response. Azathioprine is an example of an immunosuppressive drug.
  • Autoimmune disease: A condition in which your immune system mistakenly attacks your body. Azathioprine is used in the treatment of certain autoimmune diseases.
  • Rheumatoid arthritis: A chronic inflammatory disorder affecting many joints, including those in the hands and feet. Azathioprine is used in the treatment of rheumatoid arthritis.
  • Lymphoma: A type of cancer that begins in infection-fighting cells of the immune system. There is an increased risk of lymphoma with the use of Azathioprine.

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