WikiMD is the world's largest medical encyclopedia with
29,039 pages, 4,107,628 edits & 35,806,679 views.
Azacitidine
azacitidine (ay-zuh-SY-tih-deen) is a drug used to treat myelodysplastic syndromes. It is also being studied in the treatment of other conditions and types of cancer.
How does it work?
Azacitidine stops cells from making DNA and may kill abnormal blood cells or cancer cells. It is a type of antimetabolite. Also called Vidaza.
Liver safety of Azacitidine
Azacitidine is associated with a low rate of transient serum enzyme elevations during therapy and has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice.
Mechanism of action of Azacitidine
Azacitidine (ay" za sye' ti deen: also spelled azacytidine) is a pyrimidine analogue (5-azacytidine) which is converted intracellularly to a triphosphate which becomes incorporated into RNA and DNA. While azacitidine has anticancer effects, it proved to have limited usefulness in solid tumors and lymphomas. In low doses, azacitidine inhibits methylation of DNA and results in the expression of silenced genes, including tumor suppressor genes. Studies done in vitro and in vivo have shown that azacitidine induces differentiation of bone marrow cells and results in normalization of bone marrow in a proportion of patients with myelodysplasia.
FDA approval information for Azacitidine
Azacitidine was approved for use in the United States in 2004 and the current single indication is for therapy of myelodysplastic syndromes. It is also under evaluation as therapy of acute myelogenous leukemia. Azacitidine is available as a powder for injection in 100 mg vials under the trade name of Vidaza. An oral formulation is currently under evaluation.
Dosage and administration for Azacitidine
The usual initial dosage regimen in adults is 75 mg per meter-squared body surface area subcutaneously each day for 7 days, with repeat courses after 28 days. A minimum of 4 courses is recommended and the dose can be increased based upon tolerance and response.
Side effects of Azacitidine
Common side effects include bone marrow suppression, nausea, vomiting, diarrhea, stomatitis, bruising, abdominal pain, myalgias, headache, dizziness, fatigue, fever, rash and pruritus.
Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ
Cost and Coupons - Azacitidine
- GoodRx compare cost & coupons for Azacitidine
- Find the lowest cost of Azacitidine
- Search for Coupons for Azacitidine
Reviews for Azacitidine
Learn more about Azacitidine
- Dailymed label info
- Scientific articles
- Drug portal Azacitidine
- toxicity info on Azacitidine
- FDA Azacitidine
Latest research (Pubmed)
External links
WikiMD needs you!
This WikiMD article Azacitidine is a stub.
If you are a healthcare professional familiar with the topic Azacitidine, or
A subject matter expert or authority on Azacitidine, you can help us.
About | Mission | Paid editors welcome!
| Azacitidine is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever! |
|---|
| Medicine: Health - Encyclopedia - Topics - Diseases - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers |
 Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP* |
