Autoantigens
Autoantigens (pronunciation: /ˌɔːtoʊˈæntɪdʒənz/) are proteins, or complexes of proteins and other biological molecules, that are recognized by the immune system of patients suffering from a specific autoimmune disease.
Etymology
The term "autoantigen" is derived from the Greek words "autos" meaning self, and "antigen", from "anti" (against) and "gen" (that which generates).
Definition
An autoantigen is a normal protein or complex of proteins (and sometimes DNA or RNA) that is recognized by the immune system of patients suffering from a specific autoimmune disease. These proteins are usually located within the cell or on the cell surface and, in health, are protected from the immune system. However, in autoimmune diseases, these proteins can be presented to the immune system and an immune response to them can be mounted, causing disease.
Related Terms
- Autoimmunity: The system of immune responses of an organism against its own healthy cells and tissues.
- Autoimmune disease: A condition arising from an abnormal immune response to a normal body part.
- Antigen: A substance that binds to a specific antibody and causes an immune response.
- Immune system: A host defense system comprising many biological structures and processes within an organism that protects against disease.
See Also
References
External links
- Medical encyclopedia article on Autoantigens
- Wikipedia's article - Autoantigens
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