Astemizole
Astemizole (pronounced as as-TEM-i-zole) is a long-acting, non-sedating antihistamine that was previously used to treat allergic conditions such as hay fever and urticaria. It was withdrawn from the market due to the risk of serious cardiac side effects.
Etymology
The term "Astemizole" is derived from the Greek words "Aste" meaning "without" and "mizo" meaning "mix". This refers to the drug's ability to act without causing sedation, a common side effect of many antihistamines.
Pharmacology
Astemizole works by blocking the effects of histamine, a substance in the body that causes allergic symptoms. It is a selective histamine H1 antagonist, meaning it specifically targets H1 histamine receptors.
Side Effects
The most serious side effect of astemizole is its potential to cause QT interval prolongation, a heart rhythm disorder that can cause serious irregular heartbeats, fainting, or sudden death. Other side effects may include drowsiness, dry mouth, and headache.
History
Astemizole was first approved for use in the United States in 1988. However, it was withdrawn from the market in 1999 due to concerns about its safety, particularly its potential to cause serious cardiac side effects.
Related Terms
External links
- Medical encyclopedia article on Astemizole
- Wikipedia's article - Astemizole
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