Arthus reaction
Arthus Reaction
The Arthus Reaction (pronounced: ar-thus ree-ak-shun) is a localized subacute or chronic hypersensitivity reaction that occurs in the skin following the injection of an antigen to which the organism has been previously sensitized.
Etymology
The term "Arthus Reaction" is named after the French scientist Nicolas Maurice Arthus who first described the reaction in 1903.
Definition
The Arthus Reaction is a type III hypersensitivity reaction that is characterized by severe local inflammation, primarily caused by the deposition of immune complexes in the walls of small blood vessels. The reaction is most commonly observed in the skin, but can also affect other organs and tissues in the body.
Mechanism
The Arthus Reaction occurs when an antigen is injected into a site that contains high concentrations of specific antibody. The antigen and antibody bind to form immune complexes, which deposit in the walls of local blood vessels. This triggers a series of events that lead to inflammation, vasculitis, and tissue damage.
Related Terms
See Also
External links
- Medical encyclopedia article on Arthus reaction
- Wikipedia's article - Arthus reaction
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