Sertoli–Leydig cell tumour
Sertoli–Leydig cell tumour
Sertoli–Leydig cell tumour (pronunciation: ser-toh-lee ley-dig sel too-mer), also known as androblastoma, is a rare type of ovarian cancer that originates from the sex cord-stromal cells of the ovary.
Etymology
The term "Sertoli–Leydig cell tumour" is named after the two types of cells from which the tumour originates: the Sertoli cells and the Leydig cells. Sertoli cells are named after the Italian physiologist, Enrico Sertoli, who discovered them. Leydig cells are named after the German anatomist, Franz von Leydig, who first described them.
Definition
A Sertoli–Leydig cell tumour is a type of neoplasm that primarily occurs in the ovaries. It is part of a larger group of tumours known as sex cord-stromal tumours, which also includes granulosa cell tumours and theca cell tumours. These tumours are characterized by their origin from the sex cord-stromal cells, which are responsible for sex hormone production and regulation in the ovaries.
Symptoms
Common symptoms of a Sertoli–Leydig cell tumour include abdominal pain, a palpable abdominal mass, and virilization due to the excessive production of male sex hormones (androgens) by the tumour. Virilization may lead to symptoms such as deepening of the voice, increased body hair, and enlargement of the clitoris.
Diagnosis
Diagnosis of a Sertoli–Leydig cell tumour typically involves a combination of medical imaging techniques, such as ultrasound and computed tomography (CT) scans, and laboratory tests to measure levels of sex hormones in the blood. A definitive diagnosis is usually made through a biopsy of the tumour.
Treatment
Treatment for a Sertoli–Leydig cell tumour usually involves surgery to remove the tumour, often followed by chemotherapy or radiotherapy to kill any remaining cancer cells. The prognosis for patients with a Sertoli–Leydig cell tumour is generally good, especially if the tumour is detected and treated early.
External links
- Medical encyclopedia article on Sertoli–Leydig cell tumour
- Wikipedia's article - Sertoli–Leydig cell tumour
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