Arbaclofen placarbil
Arbaclofen Placarbil
Arbaclofen Placarbil (pronunciation: ar-ba-clo-fen pla-car-bil) is a prodrug of R-baclofen, which is a gamma-aminobutyric acid (GABA) B receptor agonist.
Etymology
The name "Arbaclofen" is derived from the active ingredient "R-baclofen", while "Placarbil" refers to the prodrug technology used to improve the drug's absorption and bioavailability.
Pharmacology
Arbaclofen Placarbil is designed to overcome the limitations of R-baclofen, which include poor bioavailability and a short half-life. It is converted to R-baclofen in the body, which then acts on the GABA B receptors. This action helps to reduce the release of excitatory neurotransmitters, thereby reducing spasticity and improving motor function.
Clinical Use
Arbaclofen Placarbil has been investigated for use in several neurological disorders, including spasticity associated with multiple sclerosis, Huntington's disease, and cerebral palsy. It has also been studied for its potential use in treating alcoholism and fragile X syndrome.
Related Terms
- Prodrug: A medication or compound that, after administration, is metabolized into a pharmacologically active drug.
- R-baclofen: The active ingredient in Arbaclofen Placarbil.
- GABA B receptor: A type of GABA receptor that Arbaclofen Placarbil acts upon.
- Bioavailability: The proportion of a drug or other substance which enters the circulation when introduced into the body and so is able to have an active effect.
- Spasticity: A condition in which certain muscles are continuously contracted.
- Multiple Sclerosis: A chronic disease that affects the central nervous system, especially the brain and spinal cord.
- Huntington's Disease: A genetic disorder that causes progressive deterioration of brain cells.
- Cerebral Palsy: A group of disorders that affect a person's ability to move and maintain balance and posture.
- Alcoholism: A chronic disease characterized by uncontrolled drinking and preoccupation with alcohol.
- Fragile X Syndrome: A genetic condition that causes a range of developmental problems including learning disabilities and cognitive impairment.
External links
- Medical encyclopedia article on Arbaclofen placarbil
- Wikipedia's article - Arbaclofen placarbil
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