Amylin

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Amylin

Amylin or islet amyloid polypeptide (IAPP) is a peptide hormone that is co-secreted with insulin from the pancreatic beta cells in response to nutrient stimuli. The term "amylin" is derived from the words "amyloid" and "insulin" due to its identification in insulinoma amyloid deposits.

Pronunciation

Amylin is pronounced as /ˈæmɪlɪn/.

Etymology

The term "amylin" is a combination of the words "amyloid", which refers to a type of protein that can fold into many different shapes, and "insulin", a hormone that regulates the metabolism of carbohydrates and fats.

Function

Amylin functions to slow gastric emptying, suppress glucagon secretion, and regulate satiety. It is implicated in the pathogenesis of Type 2 diabetes due to its ability to form amyloid fibrils in the pancreatic islets, leading to beta-cell destruction.

Related Terms

  • Insulin: A hormone that regulates the amount of glucose in the blood. Amylin is co-secreted with insulin from the pancreatic beta cells.
  • Pancreatic beta cells: These cells are located in the pancreas and are responsible for producing insulin and amylin.
  • Peptide hormone: A type of hormone made up of amino acids. Amylin is a peptide hormone.
  • Type 2 diabetes: A chronic condition that affects the way the body processes blood sugar (glucose). Amylin is implicated in the pathogenesis of Type 2 diabetes.

See Also

External links

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