Amsterdam criteria
Amsterdam Criteria
The Amsterdam Criteria (pronounced: /ˈæmstərdæm kraɪˈtɪəriə/) are a set of diagnostic criteria used to identify families with Hereditary Nonpolyposis Colorectal Cancer (HNPCC), also known as Lynch Syndrome. The criteria were first proposed in Amsterdam in 1990 by a group of international experts, hence the name.
Etymology
The term "Amsterdam Criteria" is derived from the city of Amsterdam, where the criteria were first proposed during a conference in 1990. The word "criteria" is a plural form of the Latin word "criterium", which means a standard or rule for judging something.
Definition
The Amsterdam Criteria are defined as follows:
1. At least three relatives must have a cancer associated with HNPCC, one of whom is a first-degree relative of the other two. 2. At least two successive generations must be affected. 3. At least one of the relatives with cancer associated with HNPCC should be diagnosed before the age of 50. 4. Familial adenomatous polyposis (FAP) should be excluded. 5. Tumors should be verified by pathologic examination.
Related Terms
- Hereditary Nonpolyposis Colorectal Cancer (HNPCC): A type of inherited cancer of the digestive tract, particularly the colon and rectum.
- Lynch Syndrome: Another name for HNPCC, named after Dr. Henry T. Lynch who first described the syndrome.
- Familial Adenomatous Polyposis (FAP): A different type of inherited colorectal cancer that should be excluded when diagnosing HNPCC.
See Also
External links
- Medical encyclopedia article on Amsterdam criteria
- Wikipedia's article - Amsterdam criteria
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