Allosteric modulator

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Allosteric Modulator

Allosteric modulator (pronunciation: al-uh-ster-ik mod-yuh-ley-ter) is a substance that indirectly influences (modulates) the effects of a primary ligand that directly activates or deactivates the function of a target protein.

Etymology

The term "allosteric modulator" is derived from the Greek words "allos" meaning "other" and "stereos" meaning "solid". This refers to the effect of the modulator on the protein's conformation or "solid" structure.

Function

An allosteric modulator binds to a protein at a site different from the active site of the primary ligand. This binding causes a conformational change in the protein, which can either enhance or inhibit the activity of the primary ligand. Allosteric modulators are important in many biological processes, including signal transduction, gene regulation, and enzyme activity.

Types

There are two main types of allosteric modulators: positive and negative. Positive allosteric modulators (PAMs) enhance the activity of the primary ligand, while negative allosteric modulators (NAMs) inhibit the activity of the primary ligand.

Related Terms

See Also

External links

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