W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
28,766 pages, 4,106,743 edits & 35,575,713 views.

Free unbiased diet, health and wellness info!

Alkaline tide

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Alkaline tide refers to a condition, normally encountered after eating a meal, where during the production of HCl by parietal cells in the stomach, the parietal cells also secrete bicarbonate ions across their basolateral membranes and into the interstitial fluid, causing a temporary increase in pH.

During hydrochloric acid secretion in the stomach, the gastric parietal cells extract chloride anions, carbon dioxide, water and sodium cations from the blood plasma and in turn release bicarbonate back into the plasma after forming it from carbon dioxide and water constituents. This is to maintain the plasma's electrical balance, as the chloride anions have been extracted. The bicarbonate content causes the venous blood leaving the stomach to be more alkaline than the arterial blood delivered to it.

Post-prandial (i.e., after a meal) alkaline tide lasts until the acids in food absorbed in the small intestine reunite with the bicarbonate that was produced when the food was in the stomach. Thus, alkaline tide is self-limited and normally lasts less than two hours.

Post-prandial alkaline tide has also been shown to be a causative agent of calcium oxalate urinary stones in cats,[1] and potentially in other species[2]

A more pronounced alkaline tide results from vomiting, which stimulates hyperactivity of gastric parietal cells to replace lost stomach acid (verification needed). Thus, protracted vomiting can result in metabolic alkalosis.[citation needed]


  1. Taton DF, Hamar D, Lewis LD. Evaluation of ammonium chloride as a urinary acidifier in the cat. Journal of the American Veterinary Medical Association 1984; 184: 433-436.
  2. McGavin, MD., Zachary, JF. Pathologic Basis of Veterinary Disease, Fourth Edition, Mosby, 2007, pp. 680-686.

W8MD and WikiMD founder

W8MD weight loss, sleep and medspa centers


King of Prussia

New Jersey

New York

Other weight loss blogs

W8MD's tele-weight loss - Call (718)946-5500 (NY, NJ) or (215)676-2334 for PA.

I would most definitely recommend to go to here. They are very nice helpful and know what they are doing and talking about, I can see that the doctor has experience for sure. - A patient.

Alkaline tide is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever!
Medicine: Health - Encyclopedia‏‎‏‎ - Topics‏‎ -‏‎ Diseases‏‎ - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity‏‎ - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP*
Special: W8MD's tele-weight loss consultations only $99.99. Call 718-946-5500. Limited acceptance.