W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
29,050 pages, 4,107,681 edits & 35,855,462 views.

Free unbiased diet, health and wellness info!

Alectinib

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

alectinib

An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, alectinib binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors. The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.

Clinical use of Alectinib

Alectinib is a tyrosine kinase receptor inhibitor and antineoplastic agent used in the therapy of selected forms of advanced non-small cell lung cancer.  

Alectinib
Alectinib

Liver safety of Alectinib

Alectinib is associated with a moderate rate of transient elevations in serum aminotransferase levels during therapy and with rare instances of clinically apparent acute liver injury

Mechanism of action of Alectinib

Alectinib (al ek' ti nib) is a small molecule tyrosine kinase receptor inhibitor with potent activity against anaplastic lymphoma kinase (ALK) that is rearranged and mutated in slective cancers, including approximately 5% of non-small cell lung cancer (NSCLC).  The mutated, rearranged ALK promotes unregulated cell growth and proliferation and is sometimes overexpressed in cancer cells.  Alectinib has been found to inhibit mutated ALK in cell culture and in several clinical trials was found to induce objective responses in a proportion of patients with refractory, advanced NSCLC that are ALK-positive. 

FDA approval information for Alectinib

Alectinib was approved for use in the United States in 2015 in patients with ALK-positive, metastatic NSCLC who have progressed despite therapy with first generation ALK inhibitors (such as crizotinib). 

Dosage and administration for Alectinib

Alectinib is available in capsules of 150 mg under the brand name Alecensa.  The recommended dose is 600 mg twice daily, continued until disease progression or intolerable toxicity occurs. 

Side effects of Alectinib

Side effects are common and can include fatigue, constipation, peripheral edema and myalgia.  Uncommon, but potentially severe side effects include interstitial lung disease, severe myopathy, bradycardia and fetal toxicity.  Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ

 

Cost and Coupons - Alectinib

Reviews for Alectinib

Learn more about Alectinib

Latest research (Pubmed)

PubMed
Wikipedia

External links


edit 

WikiMD needs you!

This WikiMD article Alectinib is a stub.
If you are a healthcare professional familiar with the topic Alectinib, or
A subject matter expert or authority on Alectinib, you can help us.
About | Mission | Paid editors welcome!

Alectinib is part of WikiMD's ^articles available 4free, 4all & 4ever!
^The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional advice
WIKIMD MAKES NO GUARANTEE OF VALIDITY OF CONTENT. USE THE CONTENT AT YOUR OWN RISK!

A very small portion of the content such as templates etc., when imported from wikipedia, are licensed under CC BY-SA 3.0. ^See full disclaimers and terms of use

W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP*
Special: W8MD's tele-weight loss consultations only $99.99. Call 718-946-5500. Limited acceptance.