Alatrofloxacin

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Alatrofloxacin

Alatrofloxacin (/ˌælətroʊˈflɒksəsɪn/) is a fluoroquinolone antibiotic that was used in the form of its mesylate ester, alatrofloxacin mesylate. It is a prodrug of trovafloxacin.

Etymology

The term "Alatrofloxacin" is derived from the parent drug "Trovafloxacin," with the prefix "Ala-" indicating the alanine moiety added to make the prodrug.

Pharmacology

Alatrofloxacin is administered intravenously and is converted to trovafloxacin, its active metabolite, in the liver. Trovafloxacin exerts its antibacterial activity by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.

Clinical Use

Alatrofloxacin was used to treat adults with lower respiratory tract infections and complicated skin and skin structure infections caused by susceptible strains of certain bacteria. However, its use was discontinued due to hepatotoxicity concerns.

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