Active metabolite
Active Metabolite
An Active Metabolite (pronunciation: /ˈæktɪv mɪˈtæbəlaɪt/) is a biologically active compound that is the product of metabolism.
Etymology
The term "Active Metabolite" is derived from the words "active", meaning having a role or function, and "metabolite", which comes from the Greek word "metabole" meaning change.
Definition
An Active Metabolite is a biotransformation product of a parent drug or chemical compound that has pharmacological activity similar to or greater than the parent compound. These metabolites are usually formed in the body by enzymatic processes, primarily in the liver, and can have significant effects on the body's function.
Related Terms
- Prodrug: A compound that, upon administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacologically active drug.
- Pharmacokinetics: The study of how an organism affects a drug, including absorption, distribution, metabolism, and excretion.
- Pharmacodynamics: The study of the biochemical and physiological effects of drugs and their mechanisms of action.
- Enzyme: Proteins that act as catalysts within living cells, regulating the rate at which reactions occur without being consumed by the reaction.
- Liver: The largest gland in the body, playing a major role in metabolism with numerous functions in the human body, including detoxification, protein synthesis, and production of biochemicals necessary for digestion.
External links
- Medical encyclopedia article on Active metabolite
- Wikipedia's article - Active metabolite
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