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Information about Acrivastine

Acrivastine is a second generation antihistamine that is used for the treatment of allergic rhinitis.

Liver safety of Acrivastine

Acrivastine has not been linked to instances of clinically apparent acute liver injury.

Mechanism of action of Acrivastine

Acrivastine (ak" ri vas' teen) is a second generation antihistamine (H1 receptor blocker) that is used to treat allergic symptoms associated with hay fever, seasonal allergies, urticaria, angioedema and atopic dermatitis. Acrivastine, like other second generation antihistamines, is considered to be nonsedating, and prospective studies have shown that sedation is less common with acrivastine than first generation antihistamines such as diphenhydramine.

Brand name for Acrivastine

In the United States, acrivastine is available in combination with pseudoephrine (Semprex-D) as therapy of seasonal allergic rhinitis. Acrivastine has been less popular than other second generation antihistamines such as loratadine and cetirizine, probably because it requires three times a day dosing.

Dosage and administration for Acrivastine

The recommended dose in adults is 4 to 8 mg two or three times daily.

Side effects of Acrivastine

Common side effects include blurred vision, dry mouth and throat, palpitations, tachycardia, abdominal distress, constipation and headache. Although considered to be a nonsedating antihistamine, acrivastine may cause mild drowsiness particularly at higher doses. Antihistamines can worsen urinary retention and glaucoma. First Generation Antihistamines

Second Generation Antihistamines

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