Aberrant crypt foci

Aberrant Crypt Foci (pronunciation: a-ber-rant kript foh-sigh) is a term used in the field of Gastroenterology and Oncology to describe abnormal clusters of cells in the lining of the colon and rectum. These clusters are considered to be precursors to polyps, which can eventually develop into colorectal cancer.

Etymology

The term "Aberrant Crypt Foci" is derived from the Latin word "aberrare" meaning to deviate or go astray, and the Greek word "kryptos" meaning hidden. The term "foci" is the plural form of the Latin word "focus", meaning point or center. Thus, the term refers to abnormal, hidden points or centers in the colon or rectum.

Definition

Aberrant Crypt Foci (ACF) are microscopic lesions that are considered the earliest identifiable precursors of colorectal cancer. They are characterized by their abnormal size, shape, and increased pericryptal area compared to normal crypts. ACF are often identified in the colon and rectum during colonoscopy procedures.

Clinical Significance

ACF are considered significant in the study of colorectal cancer because they are believed to be the first step in the adenoma-carcinoma sequence. This sequence is a series of events that describe the transformation of normal colonic epithelium to adenoma and eventually to carcinoma. The presence of ACF may indicate an increased risk of developing colorectal cancer.

Related Terms

• Adenoma
• Colorectal cancer
• Gastroenterology
• Oncology
• Polyp

External links

• Medical encyclopedia article on Aberrant crypt foci
• Wikipedia's article - Aberrant crypt foci

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