ALOX12B

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ALOX12B

ALOX12B (pronounced as A-L-O-X-12-B), also known as Arachidonate 12-Lipoxygenase, 12R Type, is a gene that encodes a member of the lipoxygenase family of enzymes. It is involved in the metabolism of arachidonic acid and plays a significant role in the skin barrier function.

Etymology

The term ALOX12B is an abbreviation derived from Arachidonate 12-Lipoxygenase, 12R Type. The term 'Arachidonate' refers to arachidonic acid, a polyunsaturated omega-6 fatty acid, while 'Lipoxygenase' is an enzyme that oxygenates lipids. The '12R' denotes the specific type of lipoxygenase that this gene encodes.

Function

The ALOX12B gene is part of the lipoxygenase pathway, which is a key component in the biosynthesis of leukotrienes, lipoxins, and other bioactive lipids. The enzyme encoded by this gene converts arachidonic acid exclusively to 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE), and further metabolizes it to hepoxilins. These hepoxilins are involved in the formation of the skin barrier, making the ALOX12B gene crucial for skin health.

Related Terms

  • Arachidonic Acid: A polyunsaturated omega-6 fatty acid involved in the metabolism of the ALOX12B gene.
  • Lipoxygenase: An enzyme that oxygenates lipids, encoded by the ALOX12B gene.
  • Leukotrienes: Bioactive lipids synthesized as part of the lipoxygenase pathway.
  • Lipoxins: Another type of bioactive lipids synthesized as part of the lipoxygenase pathway.
  • Hepoxilins: Metabolites of 12R-HPETE, involved in the formation of the skin barrier.

See Also

External links

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