AFLP
AFLP (Acute Fatty Liver of Pregnancy) is a rare, life-threatening complication that occurs in the third trimester or early postpartum period. It is characterized by the accumulation of fat in the liver, leading to liver damage.
Etiology
The exact cause of AFLP is unknown, but it is believed to be related to a defect in the mother's ability to metabolize fatty acids. This defect is thought to be triggered by the presence of the fetus. Pregnancy is the only known risk factor for AFLP.
Symptoms
The symptoms of AFLP can vary, but often include nausea, vomiting, abdominal pain, jaundice, and general malaise. In severe cases, it can lead to liver failure, renal failure, and complications for both the mother and the fetus.
Diagnosis
AFLP is typically diagnosed through a combination of clinical symptoms and laboratory tests. These tests may include liver function tests, coagulation studies, and a liver biopsy. Imaging studies such as an ultrasound or CT scan may also be used.
Treatment
The primary treatment for AFLP is delivery of the fetus, as the condition typically resolves once the fetus is no longer present. In severe cases, the mother may require intensive care and treatment for complications such as liver or renal failure.
Prognosis
With early diagnosis and treatment, the prognosis for AFLP is generally good. However, if left untreated, it can lead to serious complications for both the mother and the fetus, including death.
See Also
External links
- Medical encyclopedia article on AFLP
- Wikipedia's article - AFLP
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