8-methoxy-psoralen

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8-Methoxy-Psoralen

8-Methoxy-Psoralen (pronunciation: 8-Meth-ox-ee-Pso-ral-en), also known as 8-MOP or Methoxsalen, is a furocoumarin and psoralen derivative. It is a natural organic compound which is widely used in PUVA therapy for the treatment of psoriasis, eczema, vitiligo, and some cutaneous lymphomas.

Etymology

The term "8-Methoxy-Psoralen" is derived from its chemical structure. The "8-Methoxy" part refers to the methoxy group (-OCH3) attached at the 8th position of the psoralen molecule. "Psoralen" is a type of furocoumarin, a class of organic chemical compounds produced by a variety of plants.

Usage

8-Methoxy-Psoralen is used in combination with UVA irradiation (PUVA treatment) to treat skin disorders. The compound is ingested or applied topically, and then the affected skin is exposed to UVA. 8-Methoxy-Psoralen intercalates into DNA, where it is activated by UVA to form covalent links with the DNA, leading to cross-linking of the DNA and triggering apoptosis of the abnormal skin cells.

Related Terms

  • Furocoumarin: A class of organic chemical compounds produced by a variety of plants.
  • Psoralen: A type of furocoumarin, which is used in PUVA therapy.
  • PUVA therapy: A type of phototherapy for skin diseases, using psoralen and UVA radiation.
  • Psoriasis: A chronic skin disease characterized by red patches covered with scales.
  • Eczema: A condition that makes your skin red and itchy.
  • Vitiligo: A long-term skin condition characterized by patches of the skin losing their pigment.
  • Lymphoma: A type of cancer that begins in infection-fighting cells of the immune system.

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