4-hydroxytamoxifen

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4-Hydroxytamoxifen

4-Hydroxytamoxifen (pronounced as four-hydroxy-tamoxifen) is a selective estrogen receptor modulator (SERM) that is widely used in the treatment of breast cancer.

Etymology

The term "4-Hydroxytamoxifen" is derived from its chemical structure, which includes a hydroxy group (-OH) at the 4th position of the tamoxifen molecule.

Pharmacology

4-Hydroxytamoxifen is a metabolite of tamoxifen, produced in the body by the action of the enzyme cytochrome P450 2D6 (CYP2D6). It binds to estrogen receptors in the body, blocking the effects of estrogen and thereby inhibiting the growth of estrogen-dependent breast cancer cells.

Clinical Use

4-Hydroxytamoxifen is used primarily in the treatment of estrogen receptor-positive breast cancer, both in pre- and post-menopausal women. It is also used in the prevention of breast cancer in women at high risk of developing the disease.

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