4-NQO
4-NQO
4-Nitroquinoline 1-oxide (pronounced as four-nitro-quin-o-line one-oxide), commonly abbreviated as 4-NQO, is a quinoline derivative and a potent carcinogen.
Etymology
The term 4-NQO is derived from its chemical structure, which consists of a quinoline ring with a nitro group at the 4th position and an oxide group at the 1st position.
Definition
4-NQO is a synthetic compound that is primarily used in biological research to induce mutations in organisms. It is a potent carcinogen that can cause various types of cancer in animals, including skin, lung, and oral cancers.
Usage
In research, 4-NQO is often used to study the mechanisms of carcinogenesis and DNA repair. It is also used to create animal models of human cancers for the development and testing of new cancer therapies.
Related Terms
- Carcinogen: A substance capable of causing cancer in living tissue.
- Quinoline: A heterocyclic aromatic organic compound with the chemical formula C9H7N.
- DNA repair: The collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.
- Carcinogenesis: The formation of a cancer, whereby normal cells are transformed into cancer cells.
See Also
External links
- Medical encyclopedia article on 4-NQO
- Wikipedia's article - 4-NQO
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