4'-Hydroxynorendoxifen
4'-Hydroxynorendoxifen
4'-Hydroxynorendoxifen (pronunciation: four-prime-hydroxy-nor-endoxifen) is a metabolite of the drug tamoxifen, which is commonly used in the treatment of breast cancer.
Etymology
The term "4'-Hydroxynorendoxifen" is derived from its chemical structure. The "4'" refers to the position of the hydroxy group on the molecule, "nor" indicates the absence of a methyl group compared to endoxifen, and "endoxifen" is the parent compound from which it is metabolized.
Pharmacology
4'-Hydroxynorendoxifen is produced in the body by the action of the enzyme CYP2D6, which metabolizes tamoxifen into various metabolites, including 4'-Hydroxynorendoxifen. This metabolite has been found to have potent anti-estrogenic activity, similar to that of tamoxifen, making it an important component of tamoxifen's therapeutic effect.
Related Terms
- Tamoxifen: A drug used in the treatment of breast cancer.
- Metabolite: A substance produced by metabolism.
- CYP2D6: An enzyme that metabolizes many drugs, including tamoxifen.
- Endoxifen: A metabolite of tamoxifen with potent anti-estrogenic activity.
External links
- Medical encyclopedia article on 4'-Hydroxynorendoxifen
- Wikipedia's article - 4'-Hydroxynorendoxifen
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