2-hydroxyestradiol
2-Hydroxyestradiol
2-Hydroxyestradiol (pronounced as two-hydroxy-estra-diol) is a naturally occurring estrogen metabolite. It is a type of hormone that is produced in the human body.
Etymology
The term "2-Hydroxyestradiol" is derived from its chemical structure. The "2-Hydroxy" part refers to the presence of a hydroxyl group (-OH) at the 2nd carbon position of the estradiol molecule. "Estradiol" is a type of estrogen, a group of hormones that play an important role in the reproductive and sexual development in females.
Function
2-Hydroxyestradiol is produced from estradiol by the action of the enzyme cytochrome P450 1B1. It has both estrogenic and anti-estrogenic activity, and has been shown to inhibit the growth of certain types of breast cancer cells. It is also involved in the regulation of angiogenesis, the process by which new blood vessels form from pre-existing vessels.
Related Terms
- Estrogen: A group of hormones that play an important role in the reproductive and sexual development in females.
- Estradiol: The most potent naturally occurring estrogen in humans.
- Cytochrome P450 1B1: An enzyme that catalyzes the conversion of estradiol to 2-hydroxyestradiol.
- Breast cancer: A type of cancer that forms in the cells of the breasts.
- Angiogenesis: The physiological process through which new blood vessels form from pre-existing vessels.
External links
- Medical encyclopedia article on 2-hydroxyestradiol
- Wikipedia's article - 2-hydroxyestradiol
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