2-Aminotetralin
2-Aminotetralin
2-Aminotetralin (pronunciation: 2-uh-mee-noh-teh-truh-lin), also known as 2-AT, is a compound that belongs to the tetralin chemical class. It is a structural analog of serotonin and dopamine, two important neurotransmitters in the human brain.
Etymology
The name "2-Aminotetralin" is derived from its chemical structure. The "2-Amino" part refers to the presence of an amino group (-NH2) at the 2nd position of the tetralin ring. "Tetralin" is a contraction of "tetrahydro-naphthalene", which describes the compound's fused two-ring structure.
Chemical Structure and Properties
2-Aminotetralin is a bicyclic compound, meaning it consists of two fused rings. It has the molecular formula C10H13N. The compound is a structural analog of the neurotransmitters serotonin and dopamine, meaning it has a similar structure but is not identical.
Biological Activity
2-Aminotetralin has been found to have various effects on the central nervous system. It acts as an agonist at the serotonin 5-HT1A receptor and the dopamine D2 receptor, and as an antagonist at the serotonin 5-HT7 receptor. This means it can activate the 5-HT1A and D2 receptors, but block the 5-HT7 receptor.
Related Compounds
Related compounds to 2-Aminotetralin include other tetralin-based compounds such as 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT1A receptor agonist, and 2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin (PPHT), a selective dopamine D2 receptor agonist.
See Also
External links
- Medical encyclopedia article on 2-Aminotetralin
- Wikipedia's article - 2-Aminotetralin
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